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Transdermal Delivery of Isosorbide 5-Mononitrate from a New Membrane Reservoir and Matrix-Type Patches

1998; Taylor & Francis; Volume: 24; Issue: 5 Linguagem: Inglês

10.3109/03639049809085648

1520-5762

G. S. Arra, Srinivas Arutla, D. R. Krishna,

Advanced Drug Delivery Systems

Isosorbide 5-mononitrate (5-ISMN) has a direct relaxing effect on vascular smooth muscle. In the present study we developed matrix and reservoir-type transdermal patches of 5-ISMN. We investigated the usefulness of a new film-forming material isolated from the roots of Salacia macrosperma to serve as rate-controlling membrane for the reservoir-type patches. Matrix-type patches were formulated using polyvinyl chloride. Permeation studies through rat skin were conducted on both types of patches using Teflon cells. The mean ± SD flux values from the matrix and reservoir-type patches were 99.55 ± 22.89 and 31.82 ± 8.31μ/cm2 - hr, respectively.