The first synthesis of peptide thioester carrying N-linked core pentasaccharide through modified Fmoc thioester preparation: synthesis of an N-glycosylated Ig domain of emmprin
2003; Elsevier BV; Volume: 44; Issue: 14 Linguagem: Inglês
10.1016/s0040-4039(03)00394-0
ISSN1873-3581
AutoresHironobu Hojo, Eiichiro Haginoya, Yoshiyuki Matsumoto, Yoshiaki Nakahara, Kazuki Nabeshima, Bryan P. Toole, Yasushi Watanabe,
Tópico(s)Biochemical and Structural Characterization
ResumoPeptide thioester carrying N-linked core pentasaccharide was prepared by the Fmoc solid-phase method with a combination of the benzyl-protection strategy at the carbohydrate portion. The obtained peptide thioester was successfully used for the synthesis of the first Ig domain of emmprin composed of 61 amino acid residues.
Referência(s)