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Synthesis of a New (+)-Catechin-Derived Compound: 8-Vinylcatechin

2008; Bentham Science Publishers; Volume: 5; Issue: 7 Linguagem: Inglês

10.2174/157017808785982211

1875-6255

Luís Cruz, José E. Rodríguez‐Borges, Artur M. S. Silva, Nuno Mateus, Víctor de Freitas,

Tea Polyphenols and Effects

A strategy for the synthesis of 8-vinylcatechin was developed, which involves (+)-catechin silylation with TBDMS-Cl, followed by bromination with NBS, a cross-coupling Suzuki reaction with vinylboronic acid pinacol ester and cleavage of TBDMS groups with TBAF, affording the 8-vinylcatechin. Keywords: (+)-Catechin, silylation, bromination, Suzuki coupling, desilylation, 8-vinylcatechin