Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays
2009; Royal Society of Chemistry; Volume: 1; Issue: 1 Linguagem: Inglês
10.1039/b9nr00092e
ISSN2040-3372
AutoresTze Sian Pui, Ajay Agarwal, YE Feng, Zhi-Qiang Tou, Yinxi Huang, Peng Chen,
Tópico(s)Lipid Membrane Structure and Behavior
ResumoPerfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatible techniques. We demonstrate that these nanowire devices are able to detect adipocytokines secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such as obesity and diabetes.
Referência(s)