Notiz zur Synthese Eines Optisch Aktiven Ace‐Hemmers mit Amino‐oxo‐benzazepin‐1‐alkansäure‐Struktur mittels enantiokonvergierender kristallisationsinduzierter Racemat‐Trennung
1988; Wiley; Volume: 71; Issue: 2 Linguagem: Inglês
10.1002/hlca.19880710205
ISSN1522-2675
AutoresStephen Boyer, Rolland A. Pfund, Robert Ernst Portmann, Gottfried Sedelmeier, Hansjürg Wetter,
Tópico(s)Enzyme Catalysis and Immobilization
ResumoNote on the Synthesis of an Optically Active ACE Inhibitor with Amino‐oxo‐benzazepine‐1‐alkanoic‐Acid Structure by Means of an Enantioconvergent Crystallization‐Based Resolution An enantioselective synthesis of the potent angiotensin‐converting enzyme inhibitor (1′ S ,3 S )‐3‐[(1′‐(ethoxy‐carbonyl)‐3′‐phenylpropyl)amino]‐2,3,4,5‐tetrahydro‐2‐oxo‐1 H ‐1‐benzazepine‐1‐acetic acid hydrochloride ( 3 ) is described which user a crystallization‐based resolution of a racemic amino intermediate with concomitant racemization of the unwanted enantiomer.
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