Synthesis of 5-Substituted Pyrrolo[1,2-b]pyridazines with Antioxidant Properties
2001; Wiley; Volume: 334; Issue: 1 Linguagem: Inglês
10.1002/1521-4184(200101)334
ISSN1521-4184
AutoresOle Benny Østby, Lise‐Lotte Gundersen, Frode Rise, Øyvind Antonsen, Kjetil Fosnes, Vibeke Larsen, Aalt Bast, Ilse Custers, Guido R.M.M. Haenen,
Tópico(s)Retinoids in leukemia and cellular processes
Resumo5-Substituted pyrrolo[1,2-b]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2-b]pyridazine 5-position. Several compound exhibit profound inhibition of lipid peroxidation in vitro. Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material.
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