Transforming growth factor-beta and ovarian carcinoma cells: regulation of proliferation and surface antigen expression
1990; Elsevier BV; Volume: 51; Issue: 3 Linguagem: Inglês
10.1016/0304-3835(90)90106-8
ISSN1872-7980
AutoresChristian Marth, Thomas Lang, A. Koza, I. Mayer, G. Daxenbichler,
Tópico(s)Angiogenesis and VEGF in Cancer
ResumoTransforming growth factor-beta (TGF-beta) is a multifunctional peptide regulating several processes in ovarian cells. The growth of ovarian carcinoma cell lines (OVCAR-3, HTB-77, 2780 and CRL-1572) was reduced by TGF-beta in a dose related manner. The antiproliferative activity was not improved by combination with other biological response modifiers. Treatment with TGF-beta augmented the expression of interferon-gamma induced class I and II antigens of the major histocompatibility complex. The presentation of another antigen namely the tumor marker CA-125 on the cell surface was markedly reduced by TGF-beta.
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