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Maternal medicine: Increased serum phosphodiesterase activity in women with pre‐eclampsia

2006; Wiley; Volume: 113; Issue: 5 Linguagem: Inglês

10.1111/j.1471-0528.2006.00916.x

1471-0528

Bartira Ercí­lia Pinheiro da Costa, Caio Augusto Scocco, Carlos Eduardo Poli‐de‐Figueiredo, Jorge A. Guimarães,

Maternal and fetal healthcare

Objective To measure the activity of serum phosphodiesterase (PDE) in pre‐eclampsia. Design Case–control study. Setting Nephrology Laboratory and Obstetrics Unit at São Lucas Hospital from Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. Sample Twenty‐nine normal and 28 pregnant women with pre‐eclampsia. Methods Serum was collected from women with pre‐eclampsia, at the time of diagnosis, and from gestation‐matched controls. Circulating PDE activity was assessed by measuring consumption of the substrate thymidine 5′‐monophosphate p‐nitrophenyl ester and expressed as PDE units/l. Main outcome measures Serum PDE Activity. Results Mean substrate consumption was higher in pre‐eclamptic condition ( V max = 15.8 ± 1.4 versus 12.7 ± 0.9 U/L, P = 3.7 × 10 −14 ). Conclusion These data suggest that altered PDE activity may play a role in pre‐eclampsia endothelial dysfunction.