Long-Term Management of Generalized Pustular Psoriasis with Infliximab: Case Series
2008; SAGE Publishing; Volume: 12; Issue: 4 Linguagem: Inglês
10.2310/7750.2008.07036
ISSN1615-7109
AutoresShannon B. Routhouska, Pranav Sheth, Neil J. Korman,
Tópico(s)Dermatology and Skin Diseases
ResumoBackground: Infliximab, a tumor necrosis factor α antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports. Objective: The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab. Methods: Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab. Results: Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate. Conclusion: Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.
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