Cyclic AMP in cerebrospinal fluid: Accumulation following probenecid and biogenic amines
1975; Elsevier BV; Volume: 46; Issue: 2 Linguagem: Inglês
10.1016/0014-4886(75)90139-9
ISSN1090-2430
AutoresJantiena B. Sebens, Jakob Korf,
Tópico(s)Amino Acid Enzymes and Metabolism
ResumoLevels of cyclic AMP in rabbit cisternal cerebrospinal fluid (CSF) was determined under a number of conditions. Cyclic AMP in CSF was increased by probenecid (intraperitoneally); this increase was not influenced by tricyclic antidepressant drugs, haloperidol, isoprenaline or L-DOPA. Cyclic AMP, administered intravenously, did not penetrate into CSF. Intracisternally introduced noradrenaline, isoprenaline, dopamine, histamine, and intravenously injected isoprenaline all increased the CSF levels of cyclic AMP. The results indicate that cyclic AMP in the CSF is of central origin and is eliminated by a probenecid sensitive transport mechanism. Because of the effects of biogenic amines, there seems to be a close relationship between cyclic AMP of brain tissue and of CSF. Central beta-adrenergic receptors may be measured in the intact animal by measuring the release of the nucleotide into CSF after intravenously isoprenaline. This observation may lead to a clinical applicable test for measuring properties of central adrenergic receptors.
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