Portal de Periódicos da CAPES

4-year follow-up of cardiovascular events and changes in visceral fat accumulation after health promotion program in the Amagasaki Visceral Fat Study

2010; Elsevier BV; Volume: 212; Issue: 2 Linguagem: Inglês

10.1016/j.atherosclerosis.2010.06.011

1879-1484

Yukiyoshi Okauchi, Ken Kishida, Tohru Funahashi, Midori Noguchi, Sachiko Morita, Tomoko Ogawa, Akihisa Imagawa, Tadashi Nakamura, Yūji Matsuzawa, Iichiro Shimomura,

Adipokines, Inflammation, and Metabolic Diseases

We and others have demonstrated that accumulation of intra-abdominal visceral fat precedes various obesity-related metabolic disorders, including insulin resistance, glucose intolerance, dyslipidemia, and hypertension, leading to atherosclerosis based on clustering of multiple risks [ 1 Despres J.P. Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006; 444: 881-887 Crossref PubMed Scopus (3275) Google Scholar , 2 Nakamura T. Tokunaga K. Shimomura I. et al. Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis. 1994; 107: 239-246 Abstract Full Text PDF PubMed Scopus (366) Google Scholar ]. Cardiovascular diseases are characteristically sudden in onset and life threatening in active workers, and we reported previously that management of multiple risk factors is important in preventing cardiovascular diseases in Japanese employees [ [3] Nakamura T. Tusbono Y. Kameda-Takemura K. et al. Group of the research for the association between host origin and atherosclerotic diseases under the preventive measure for work-related diseases of the Japanese Labor Ministry. Jpn Circ J. 2001; 65: 11-17 Crossref PubMed Scopus (85) Google Scholar ]. We have reported that reductions in both body weight and visceral fat area estimated by the bioelectrical impedance analysis method (estimated visceral fat area; eVFA) [ [4] Ryo M. Maeda K. Onda T. et al. A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. Diabetes Care. 2005; 28: 451-453 Crossref PubMed Scopus (219) Google Scholar ] were accompanied by reductions in the number of obesity-related cardiovascular risk factors [ [5] Okauchi Y. Nishizawa H. Funahashi T. et al. Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men. Diabetes Care. 2007; 30: 2392-2394 Crossref PubMed Scopus (90) Google Scholar ], and increases in serum levels of adiponectin [ [6] Okauchi Y. Kishida K. Funahashi T. et al. Changes in serum adiponectin concentrations correlate with changes in BMI, waist circumference, and estimated visceral fat area in middle-aged general population. Diabetes Care. 2009; 32: e122 Crossref PubMed Scopus (46) Google Scholar ] in our longitudinal Amagasaki Visceral Fat Study, in which intensive risk factor-oriented health promotion programs were provided. As an extension to the above studies, we investigated in the present study the outcome of 4-year health promotion program in middle-aged Japanese general population on cardiovascular events in relation to delta changes (Δ) in visceral fat and body mass index (BMI) (changes in test parameter during 4-year follow-up or until cardiovascular event).