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17β-Hydroxysteroid dehydrogenase inhibitors: a patent review

2010; Taylor & Francis; Volume: 20; Issue: 9 Linguagem: Inglês

10.1517/13543776.2010.505604

1744-7674

Donald Poirier,

Pharmacogenetics and Drug Metabolism

Importance of the field: 17β-Hydroxysteroid dehydrogenases (17β-HSDs) mainly catalyze the reduction of C17-ketosteroids to their corresponding hydroxylated forms as well as the reverse reaction (oxidation). Able to convert inactive or less active steroid hormones into more potent ones and vice versa, certain 17β-HSDs play a key role, especially in the regulation of estrogen and androgen levels. The therapeutic potential of this enzyme family, especially for the treatment of breast cancer, prostate cancer, acne and osteoporosis, then stimulated the development of inhibitors of 17β-HSDs and important progress was achieved over the last years.