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BIBTEX RIS

Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas

2009; Brazilian Chemical Society; Volume: 32; Issue: 9 Linguagem: Inglês

10.1590/s0100-40422009000900039

ISSN

1678-7064

Autores

Enelton Fagnani, Leonardo Pezza, Helena Redigolo Pezza,

Tópico(s)

Antibiotics Pharmacokinetics and Efficacy

Resumo

USING CHROMOTROPIC ACID AND MICROWAVE OVEN.This paper proposes a methodology for spectrophotometric determination of hexamethylenetetramine (HMT) by using chromotropic acid in a phosphoric acid media employing a domestic microwave oven as a source of heating.The reddish-purple soluble product is quantitatively formed after 30 s of irradiation and obeys the Beer´s law in the range between 0.1-1.2mg L -1 HMT (r = 0.99925).The method was applied successfully in commercial pharmaceutical preparations containing dyes in their composition.The results showed that the method proposed is feasible for simplicity, speed, low cost, precision and accuracy when compared with United States Pharmacopeia official method.

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