Portal de Periódicos da CAPES

Development of a Large-Scale De-Identified DNA Biobank to Enable Personalized Medicine

2008; Wiley; Volume: 84; Issue: 3 Linguagem: Inglês

10.1038/clpt.2008.89

1532-6535

DM Roden, JM Pulley, MA Basford, GR Bernard, Ellen Wright Clayton, JR Balser, DR Masys,

Cancer Genomics and Diagnostics

Our objective was to develop a DNA biobank linked to phenotypic data derived from an electronic medical record (EMR) system. An “opt-out” model was implemented after significant review and revision. The plan included (i) development and maintenance of a de-identified mirror image of the EMR, namely, the “synthetic derivative” (SD) and (ii) DNA extracted from discarded blood samples and linked to the SD. Surveys of patients indicated general acceptance of the concept, with only a minority (∼5%) opposing it. As a result, mechanisms to facilitate opt-out included publicity and revision of a standard “consent to treatment” form. Algorithms for sample handling and procedures for de-identification were developed and validated in order to ensure acceptable error rates (<0.3 and <0.1%, respectively). The rate of sample accrual is 700–900 samples/week. The advantages of this approach are the rate of sample acquisition and the diversity of phenotypes based on EMRs. Clinical Pharmacology & Therapeutics (2008); 84, 3, 362–369 doi:10.1038/clpt.2008.89