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Coordination of Meiotic Recombination, Pairing, and Synapsis by PHS1

2004; American Association for the Advancement of Science; Volume: 303; Issue: 5654 Linguagem: Inglês

10.1126/science.1091110

1095-9203

Wojciech P. Pawlowski, Inna Golubovskaya, Ljudmilla Timofejeva, Robert Meeley, William F. Sheridan, W. Zacheus Cande,

Mitochondrial Function and Pathology

Pairing, synapsis, and recombination are prerequisites for accurate chromosome segregation in meiosis. The phs1 gene in maize is required for pairing to occur between homologous chromosomes. In the phs1 mutant, homologous chromosome synapsis is completely replaced by synapsis between nonhomologous partners. The phs1 gene is also required for installation of the meiotic recombination machinery on chromosomes, as the mutant almost completely lacks chromosomal foci of the recombination protein RAD51. Thus, in the phs1 mutant, synapsis is uncoupled from recombination and pairing. The protein encoded by the phs1 gene likely acts in a multistep process to coordinate pairing, recombination, and synapsis.