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Small Intestinal Structure and Function in Patients Infected with Human Immunodeficiency Virus (HIV): Evidence for HIV-Induced Enteropathy

1989; American College of Physicians; Volume: 111; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-111-1-15

1539-3704

Reiner Ullrich,

Clostridium difficile and Clostridium perfringens research

Articles1 July 1989Small Intestinal Structure and Function in Patients Infected with Human Immunodeficiency Virus (HIV): Evidence for HIV-Induced EnteropathyReiner Ullrich, MB, Martin Zeitz, MD, Walter Heise, MD, Manfred L'age, MD, Gert Höffken, MD, Ernst O. Riecken, MDReiner Ullrich, MBSearch for more papers by this author, Martin Zeitz, MDSearch for more papers by this author, Walter Heise, MDSearch for more papers by this author, Manfred L'age, MDSearch for more papers by this author, Gert Höffken, MDSearch for more papers by this author, Ernst O. Riecken, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-1-15 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudy Objective: To determine small intestinal mucosal structure and function in patients with human immunodeficiency virus (HIV) infection.Design: Prospective, consecutive sample study.Setting: Referral-based medical clinics at a municipal and a university medical center.Patients: Forty-five HIV-infected patients (44 men, 1 woman) with gastrointestinal complaints.Interventions: All patients had esophagogastroduodenoscopy. Distal duodenal biopsy samples were examined morphometrically and by quantitative enzyme histochemical techniques. Immunohistologic studies were done to determine whether HIV antigen p24 was present. Biopsy and stool samples were examined for enteric pathogens and patients were evaluated for malabsorption.Measurements and Main Results: Malabsorption was common in HIV-infected patients. In 15 of 38 patients mononuclear cells infected with HIV were found in the mucosa. In 15 of 25 patients there was no detectable lactase (β-glucosidase) activity in the duodenal brush border; when measurable, lactase (β-glucosidase) activity was decreased (P < 0.02). Alkaline phosphatase activity was normal. Crypt depth was greater (P < 0.05), villous surface area was slightly smaller, and mitotic figures per crypt were not different in HIV-infected patients compared with controls. Patients without additional intestinal infection had a reduced number of mitotic figures per crypt (P < 0.05) and normal crypt depth. 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Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med. 1988;167:1341-49. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Free University of Berlin and Auguste-Viktoria Hospital, Berlin, Federal Republic of Germany. For current author addresses, see end of text. 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A preliminary reportAIDS and the gastroenterologistAIDS and the GastroenterologistCorrection: Small Intestine Structure and Infection with Human Immunodeficiency Virus (HIV)Reiner Ullrich, MB, Martin Zeitz, MDHIV-associated EnteropathyHIV and Associated Infections in the Intensive Care Unit: Perspectives from North AmericaDifferential diagnosis of colitisTreatment of AIDS Anorexia-Cachexia Syndrome and LipodystrophyHuman immunodeficiency virus (HIV) and nutrition 1 July 1989Volume 111, Issue 1Page: 15-21KeywordsAntigensAtrophyBiopsyEnzymesHIVHIV infectionsMucous membranesPathogensPhosphatasesProspective studies Issue Published: 1 July 1989 PDF downloadLoading ...