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Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars

1995; Elsevier BV; Volume: 53; Issue: 1 Linguagem: Inglês

10.1016/0278-2391(95)90486-7

1531-5053

S. Schultze-Mosgau, Rainer Schmelzeisen, J. C. Frölich, H Schmele,

Pain Mechanisms and Treatments

Abstract Purpose: To test a combination treatment of ibuprofen and methylprednisolone for pain and swelling. Methods: The efficacy of 32 mg methylprednisolone on pain and swelling when given 12 hours before and after surgery in combination with 400 mg ibuprofen three times a day given immediately on the day of the operation and on the two subsequent days following removal of impacted third molars was investigated in a placebo-controlled, intraindividual double-blind study. Results: After use of ibuprofen/methylprednisolone, ultrasonic examination showed a reduction in swelling of 56% ( P < .001) compared with the placebo group; measurement with a tape measure showed a 58% ( P < .001) reduction in swelling. The visual analog scale showed a reduction of 67.7% in postoperative pain in comparison with placebo. Conclusion: The combination of ibuprofen and methylprednisolone has good analgesic and antiinflammatory action.