Rapid Synthesis of Acyl Transfer Auxiliaries for Cysteine-Free Native Glycopeptide Ligation
2004; American Chemical Society; Volume: 6; Issue: 25 Linguagem: Inglês
10.1021/ol048145o
ISSN1523-7060
AutoresDerek Macmillan, David W. Anderson,
Tópico(s)Click Chemistry and Applications
ResumoRapid, facile routes to the TFA-cleavable 4,5,6-trimethoxy-2-mercaptobenzyl and 1-(2,4-dimethoxyphenyl)-2-mercaptoethyl classes of auxiliaries for cysteine-free native chemical ligation are described. Rapid synthesis, coupled with mild cleavage conditions will undoubtedly broaden the utility of such auxiliaries, particularly where chemically fragile peptide modifications such as glycosylation are present.
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