STUDIES WITH RADIOACTIVE COPPER (64Cu AND 67Cu) IN RELATION TO THE NATURAL HISTORY OF WILSON'S DISEASE
1967; Elsevier BV; Volume: 289; Issue: 7486 Linguagem: Inglês
10.1016/s0140-6736(67)92893-0
ISSN1474-547X
Autores Tópico(s)Trace Elements in Health
ResumoAbstract Studies with radioactive copper in patients with Wilson's disease suggest that the uptake of copper by the liver is high in the presymptomatic stage of the disease; as the illness progresses through the hepatic to the neurological stage there is a progressive fall-off in this function by the liver, presumably reflecting the saturation of the available binding sites for the metal. As the liver becomes saturated with copper the plasma is cleared more slowly, and copper can be detected more readily in other tissues. The capacity of the liver to concentrate copper can be restored, at least in some patients, by adequate long-term treatment with penicillamine.
Referência(s)