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Immunoablative therapy with autologous stem cell transplantation in the treatment of poor risk multiple sclerosis

2001; Elsevier BV; Volume: 33; Issue: 3 Linguagem: Inglês

10.1016/s0041-1345(01)01933-9

1873-2623

Tomáš Kozák, Eva Havrdová, Jiří Piťha, E Gregora, Robert Pytlík, Jacqueline Maaloufová, Petr Kobylka, Š Vodvářková,

Systemic Sclerosis and Related Diseases

Autoimmune diseases are an important field for the development of bone marrow transplantation, or hematopoietic stem cell transplantation. In Europe alone, almost 3000 procedures have been registered so far. The Brazilian Society for Bone Marrow Transplantation (Sociedade Brasileira de Transplantes de Medula Óssea) organized consensus meetings for the Autoimmune Diseases Group, to review the available literature on hematopoietic stem cell transplantation for autoimmune diseases, aiming to gather data that support the procedure for these patients. Three autoimmune diseases for which there are evidence-based indications for hematopoietic stem cell transplantation are multiple sclerosis, systemic sclerosis and Crohn's disease. The professional stem cell transplant societies in America, Europe and Brazil (Sociedade Brasileira de Transplantes de Medula Óssea) currently consider hematopoietic stem cell transplantation as a therapeutic modality for these three autoimmune diseases. This article reviews the evidence available.