Evaluation of the Antiviral and Antimicrobial Activities of Triterpenes Isolated from Euphorbia segetalis
2003; Taylor & Francis; Volume: 17; Issue: 5 Linguagem: Inglês
10.1080/14786410310001605841
ISSN1478-6427
AutoresAM Madureira, José R. Ascenso, L. Valdeira, Aida Duarte, João P. Frade, Guilherme Barroso L. De Freitas, Maria‐José U. Ferreira,
Tópico(s)Bioactive Natural Diterpenoids Research
ResumoAbstract A phytochemical reinvestigation of the whole plant of Euphorbia segetalis yielded five tetracyclic triterpenes: 3β-hydroxy-cycloart-25-en-24-one (1), cycloart-25-ene-3β,24-diol (2), cycloart-23-ene-3β,25-diol (3), lanosta-7,9(11),24-trien-3β-ol (4) and lanosta-7,9(11),24(31)-trien-3β-ol (5). 3β-acetoxy-cycloart-25-en-24-one (1a) and glutinol (6), lupenone (7), dammaranodienol (9), cycloartenol acetate (10), 24-methylenecycloartanol acetate (11) and β-sitosterol (12), isolated previously, were evaluated for their antiviral activities against Herpes simplex virus (HSV) and African swine fever virus (ASFV). Lupenone exhibited strong viral plaque inhibitory effect against HSV-1 and HSV-2. The in vitro antifungal and antibacterial activities of 1a, cycloart-23-ene-3β,25-diol, 3-acetate (3a) and 6-12 were also investigated. Keywords: Euphorbia SegetalisTetracyclic TriterpenesAntiviral ActivityHerpes Simplex VirusAfrican Swine Fever VirusAntimicrobial Activity
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