A convenient and inexpensive conversion of an aziridine to an oxazolidinone
2003; Elsevier BV; Volume: 44; Issue: 29 Linguagem: Inglês
10.1016/s0040-4039(03)01325-x
ISSN1873-3581
AutoresMatthew T. Hancock, Allan R. Pinhas,
Tópico(s)Chemical Synthesis and Reactions
ResumoThe conversion of an aziridine to the corresponding oxazolidinone using only carbon dioxide and a catalytic amount of lithium iodide is discussed. In all cases, either no reaction occurred or a high yield of product was obtained. HMPA has been added to the reaction mixture, as needed, to drastically improve the regioselectivity. Net retention of stereochemistry between the starting aziridine and the product oxazolidinone was observed.
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