Stimulation of peripheral blood lymphocytes of HIV-infected patients by jacalin, a lectin mitogenic for human CD4+ lymphocytes
1989; Lippincott Williams & Wilkins; Volume: 3; Issue: 10 Linguagem: Inglês
10.1097/00002030-198910000-00008
ISSN1473-5571
AutoresNathalie Pineau, Jean-Christophe Brugier, Jean-Philippe Breux, B Becq-Giraudon, Jean-Michel Descamps, Pièrre Aucouturier, Jean‐Louis Preud'homme,
Tópico(s)Glycosylation and Glycoproteins Research
ResumoThe proliferative response of peripheral blood mononuclear cells stimulated by jacalin was investigated in 157 samples from 104 HIV-infected patients at various clinical stages of disease. Jacalin proliferative response correlated with the absolute numbers and percentages of CD4+ lymphocytes and with the percentages of Leu 8 lymphocytes. It correlated negatively with the percentages of CD8+ and CD38+ lymphocytes. It was depressed during acute HIV infection and at advanced stages., The response in Centers for Disease Control groups II and III was heterogeneous and similar; in both, some patients showed a very low response. Further follow-up of the present patients should indicate whether jacalin responsiveness has a prognostic value.
Referência(s)