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Clinical Characteristics and Survival in Never Smokers With Lung Cancer

2014; Elsevier BV; Volume: 50; Issue: 2 Linguagem: Inglês

10.1016/j.arbr.2014.01.010

1885-6195

Isaura Parente Lamelas, José Abal Arca, Nagore Blanco Cid, Maria Perez, Raquel Dacal Quintas, Hugo Gómez Márquez, Rogelio Alejandro García Montenegro, Pedro Marcos Velázquez,

Lung Cancer Research Studies

To analyse the frequency, clinical characteristics and survival of patients with lung cancer (LC) who have never smoked in comparison to that in patients who smoke. A retrospective study in patients diagnosed with LC by cytohistology between 1999 and 2011. Survival was estimated by the Kaplan–Meier method. The χ2 test was used to estimate the relationship between the variables. A total of 2161 patients were diagnosed with LC, 396 (18.3%) of whom had never smoked. The mean age (±standard deviation) in this group was 72.85±10.52 years; 64.6% were women and 35.4% men. According to the cytohistology, 55.6% were adenocarcinoma, 20.5% squamous cell, 15% small cell, 2.7% large cell, and 6.2% other subtypes. The diagnosis was made in advanced stage (iv) in 61.4%, and 14.4% of the patients received surgical treatment. Survival was 12.4%, with no differences between the two groups. In the group of never smokers, women had better survival than men. Of the patients diagnosed with LC, 18.3% had never smoked. It was diagnosed mainly in women, at advanced stages and the most common histological type was adenocarcinoma. There were no survival differences compared to the group of smokers. Analizar la frecuencia, las características clínicas y la supervivencia de los pacientes con cáncer de pulmón nunca fumadores comparándolas con los pacientes fumadores. Estudio retrospectivo de pacientes diagnosticados de cáncer de pulmón mediante citohistología de 1999 al 2011. Se estimó la supervivencia por el método de Kaplan–Meier. Para estimar la relación entre las variables se usó la prueba de χ2. Se diagnosticaron 2.161 pacientes, 396 (18,3%) nunca fumadores. En este grupo la edad media (± desviación estándar) fue de 72,85±10,52, el 64,6% mujeres y el 35,4% hombres. Según la citohistología, el 55,6% eran adenocarcinoma, el 20,5% epidermoide, el 15% de célula pequeña, el 2,7% de célula grande y el 6,2% otros subtipos. El diagnóstico se hizo en estadio avanzado (iv) en el 61,4% de pacientes, y el 14,4% recibieron tratamiento quirúrgico. La supervivencia fue del 12,4%, sin diferencias entre los 2 grupos. En el grupo de nunca fumadores las mujeres tuvieron mejor supervivencia que los hombres. El 18,3% fueron pacientes nunca fumadores. Se diagnosticaron mayoritariamente en mujeres, estadios avanzados y estirpe histológica adenocarcinoma. No hubo diferencias de supervivencia con el grupo de fumadores.