Selective δ opioid receptor agonists for inflammatory and neuropathic pain
2001; Elsevier BV; Volume: 56; Issue: 1-2 Linguagem: Inglês
10.1016/s0014-827x(01)01020-5
ISSN1879-0569
AutoresGiulio Dondio, Silvano Ronzoni, Carlo Farina, Davide Graziani, Carlo Parini, Paola Petrillo, Giuseppe Giardina,
Tópico(s)Pharmacological Receptor Mechanisms and Effects
ResumoIn the last decade a number of selective and potent non-peptidic agents became available to explore the usefulness of the delta-opioid receptor in modulation of pain of different origins. As a continuing effort in this field, potent and selective delta-opioid agonists based on the pyrrolomorphinan framework have been designed, synthesised and characterised biologically in our laboratories. In animal models, a selected compound of interest, SB 235863, has proved the concept that selective delta-opioid agonists may have great potential as pain relief agents in inflammatory and neuropathic pain conditions. Importantly, such a compound was free of the unwanted side effects usually associated with narcotic analgesics such as morphine.
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