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STITCH 2: an interaction network database for small molecules and proteins

2009; Oxford University Press; Volume: 38; Issue: suppl_1 Linguagem: Inglês

10.1093/nar/gkp937

1362-4962

Michael Kuhn, Damian Szklarczyk, Andrea Franceschini, Mónica Campillos, Christian von Mering, Lars Juhl Jensen, Andreas Beyer, Peer Bork,

Microbial Natural Products and Biosynthesis

Over the last years, the publicly available knowledge on interactions between small molecules and proteins has been steadily increasing. To create a network of interactions, STITCH aims to integrate the data dispersed over the literature and various databases of biological pathways, drug–target relationships and binding affinities. In STITCH 2, the number of relevant interactions is increased by incorporation of BindingDB, PharmGKB and the Comparative Toxicogenomics Database. The resulting network can be explored interactively or used as the basis for large-scale analyses. To facilitate links to other chemical databases, we adopt InChIKeys that allow identification of chemicals with a short, checksum-like string. STITCH 2.0 connects proteins from 630 organisms to over 74 000 different chemicals, including 2200 drugs. STITCH can be accessed at http://stitch.embl.de/.