Sequestosome 1/p62 – More than just a scaffold
2006; Wiley; Volume: 581; Issue: 2 Linguagem: Inglês
10.1016/j.febslet.2006.12.027
ISSN1873-3468
AutoresM. Lamar Seibenhener, Thangiah Geetha, Marie W. Wooten,
Tópico(s)Cell death mechanisms and regulation
ResumoThe interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor internalization, and protein turnover. Herein we review recent advances in the field.
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