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SBA-15-collagen hybrid material for drug delivery applications

2006; Elsevier BV; Volume: 352; Issue: 32-35 Linguagem: Inglês

10.1016/j.jnoncrysol.2006.03.111

1873-4812

L.B. Fagundes, Taiane Sousa, Andreza de Sousa Andrada, V.V. Silva, Edésia Martins Barros de Sousa,

Silicone and Siloxane Chemistry

The development of mesoporous materials offers new possibilities for incorporating biological agents into silica structures and controlling the release kinetics from the matrix due to its well-arranged pore architecture. Indeed, the introduction of appropriate organic compounds into these ceramics has presented excellent results regarding drug release control. In this paper, two types of materials were used to evaluate drug delivery: SBA-15 and a hybrid SBA-15-collagen. The samples were charged with atenolol as a model drug and in vitro release assays were carried out. Significant differences were observed between the release patterns of the different materials, and the release rate was influenced by the presence of collagen in the mesopores.