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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

HLA-C –Dependent Prevention of Leukemia Relapse by Donor Activating KIR2DS1

2012; Massachusetts Medical Society; Volume: 367; Issue: 9 Linguagem: Inglês

10.1056/nejmoa1200503

ISSN

1533-4406

Autores

Jeffrey M. Venstrom, Gianfranco Pittari, Ted Gooley, Joseph H. Chewning, Stephen R. Spellman, Michael Haagenson, Meighan M. Gallagher, Mari Malkki, Effie W. Petersdorf, Bo Dupont, Katharine C. Hsu,

Tópico(s)

T-cell and B-cell Immunology

Resumo

Of the cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)–cell reactivity. The activating killer-cell immunoglobulin-like receptor (KIR) 2DS1 has ligand specificity for HLA-C2 antigens and activates NK cells in an HLA-dependent manner. Donor-derived NK reactivity controlled by KIR2DS1 and HLA could have beneficial effects in patients with AML who undergo allogeneic HSCT.

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