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Differential impact of plasma triglycerides on HDL-cholesterol and HDL-apo A-I in a large cohort

2006; Elsevier BV; Volume: 40; Issue: 1-2 Linguagem: Inglês

10.1016/j.clinbiochem.2006.06.014

1873-2933

André Tremblay, Allan D. Sniderman, Claude Gagné, Jean Bergeron, Patrick Couture,

Cancer, Lipids, and Metabolism

To examine the relationship between plasma triglycerides (TG) to HDL-cholesterol (HDL-C) or HDL apo A-I.Bivariate and multiple linear regression analyses in a large cohort of 1886 subjects.Higher plasma TG levels were associated with lower concentrations of both HDL-C and HDL-apo A-I. However, the HDL-C/HDL-apo A-I ratio was inversely correlated with plasma TG indicating that the overall composition of the HDL changed as plasma TG changed. Plasma TG levels contributed to 15.9% of the variance of the HDL-C/HDL-apo A-I ratio, whereas gender, HDL-TG, LDL-TG, body mass index and plasma apo B levels represented between 0.15% and 2.21% of this variance.These results indicate that increasing levels of plasma TG result in greater reduction in HDL-C levels than in HDL-apo A-I and this might explain, at least in part, the differences that have been observed in the magnitude of the association of HDL-C versus HDL-apo A-I with the risk of cardiovascular disease.