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Man toTrypanosome: The tubulin tyrosination/detyrosination cycle revisited

2000; Wiley; Volume: 45; Issue: 3 Linguagem: Inglês

10.1002/(sici)1097-0169(200003)45

1097-0169

Haitham T. Idriss,

Lysosomal Storage Disorders Research

Cell MotilityVolume 45, Issue 3 p. 173-184 ReviewFree Access Man to Trypanosome: The tubulin tyrosination/detyrosination cycle revisited † Haitham T. Idriss, Corresponding Author Haitham T. Idriss [email protected] Structural Biology Group, School of Biomedical Sciences, Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Scotland, United KingdomStructural Biology Group, School of Biomedical Sciences, Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Fife KY16 9ST, Scotland, UKSearch for more papers by this author Haitham T. Idriss, Corresponding Author Haitham T. Idriss [email protected] Structural Biology Group, School of Biomedical Sciences, Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Scotland, United KingdomStructural Biology Group, School of Biomedical Sciences, Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Fife KY16 9ST, Scotland, UKSearch for more papers by this author First published: 25 February 2000 https://doi.org/10.1002/(SICI)1097-0169(200003)45:3 3.0.CO;2-OCitations: 30 † The term used by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB, see http://www.chem.qmw.ac.uk/iubmb/nomenclature/) is tyrosination. It uses this in listing EC 6.3.2.25, tubulin–tyrosine ligase (see http://www.chem.qmw.ac.uk/iubmb/enzyme/). Bulinski and Gundersen [1986] give the arguments for preferring this term, based on the recommendations on naming derivatives of amino acids (see entries 3AA–1, 3AA–10.3 in http://www.chem.qmw.ac.uk/iupac/AminoAcid/). Briefly, tyrosylation would be misleading, since "tyrosyl" is the name of the acyl group, e.g., an N-terminal tyrosine residue, and acylation would suggest adding at the N-terminus. Tyrosinylation has almost the same implications, as it looks so like "tyrosyl". Tyrosinolation would also be misleading, as "tyrosinol" is defined as the alcohol in formed by reducing the COOH of tyrosine to CH2OH. Tyrosine ligation is also acceptable since TTL essentially carries out a ligation reaction. 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