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Salt-losing nephropathy

1969; Elsevier BV; Volume: 75; Issue: 5 Linguagem: Inglês

10.1016/s0022-3476(69)80314-8

1097-6833

Ori S. Better, C. Chaimowitz, B. Cellei, Chaim Lichtig, A Benderly,

Sodium Intake and Health

A case of medullary cystic disease and chronic renal failure with severe sodium wastage is described. Urinary sodium and calcium concentrations were fixed at a level approximating plasma ultrafiltrate. Renal salt loss was flow dependent. It is suggested that the main cause of the severe salt loss was a tubular and medullary defect of sodium transport; hyperfiltration and increased osmotic load per nephron played a contributory role.In the patient described, calcium was excreted in the urine in quantities that were unusually large for chronic renal failure but were commensurate with the renal salt loss.