The DASH diet enhances the blood pressure response to losartan in hypertensive patients
2003; Oxford University Press; Volume: 16; Issue: 5 Linguagem: Inglês
10.1016/s0895-7061(03)00056-6
ISSN1941-7225
Autores Tópico(s)Diet and metabolism studies
ResumoBackground:The Dietary Approaches to Stop Hypertension (DASH) diet, which emphasizes fruits, vegetables, and low fat dairy products, significantly lowers blood pressure (BP).We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension.Methods: A total of 55 hypertensive participants were randomly assigned to 8 weeks of controlled feeding with either a control diet or the DASH diet.Within each diet arm, participants received losartan 50 mg daily or placebo for 4 weeks each, in double blind, randomized, cross-over fashion.Twenty-four-hour ambulatory BP (ABP) was measured at the end of a 2-week run-in period (baseline) and after each 4-week intervention period.Results: There was no significant change in ABP during the placebo period on the control diet (n ϭ 28) (Ϫ2.3 Ϯ 1.5/Ϫ1.6Ϯ 1.0 mm Hg), but there was a significant reduction in systolic ABP (Ϫ5.3 Ϯ 1.5 mm Hg, P Ͻ .05) and no change in DBP (Ϫ2.5 Ϯ 1.0 mm Hg) on the DASH diet (n ϭ 27).Losartan significantly reduced ABP on the control diet (Ϫ6.7 Ϯ 1.5/Ϫ3.7 Ϯ 1.0 mm Hg, P Ͻ .05) and to a greater extent on the DASH diet (Ϫ11.7 Ϯ 1.5/Ϫ6.9Ϯ 1.0 mm Hg, P Ͻ .05versus basal and control diet) particularly in African Americans.On the DASH diet, ⌬SBP on losartan was inversely related to basal plasma renin activity (n ϭ Ϫ0.53, P ϭ .004). Conclusions:The DASH diet enhances the ABP response to losartan in essential hypertension.This effect is particularly marked in African Americans.
Referência(s)