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Metal complexes of anti-inflammatory drugs. Part IV. Tenoxicam complexes of manganese(II), iron(III), cobalt(II), nickel(II) and copper(II)

1987; Elsevier BV; Volume: 138; Issue: 1 Linguagem: Inglês

10.1016/s0020-1693(00)81186-x

1873-3255

Adrian Bury, Allan E. Underhill, D. R. Kemp, N. J. O'SHEA, John Smith, P. S. GOMM,

Synthesis and Characterization of Heterocyclic Compounds

The preparation, spectroscopic and magnetic properties are reported for complexes of manganese(II), iron(III), cobalt(II), nickel(II) and copper(II) with the anti-inflammatory drug tenoxicam. In all the complexes studied the tenoxicam acts as a chelate monoanionic ligand with coordination involving the enolate oxygen atom and the carbonyl oxygen atom of the amide group. The complexes appear to have an octahedral stereochemistry involving two chelate tenoxicam ligands in the case of divalent central metal ions and three chelate tenoxicam ligands in the iron(III) complex. The manganese(II) and copper(II) complexes exhibit marked superoxide dismutase activity in the nitroblue tetrazolium assay.