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Discovery of a novel nitroimidazolyl–oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation

2010; Elsevier BV; Volume: 46; Issue: 1 Linguagem: Inglês

10.1016/j.ejmech.2010.10.015

1768-3254

Ali Khalaj, Maryam Nakhjiri, Amirsoheil Negahbani, Marjaneh Samadizadeh, Loghman Firoozpour, Saeed Rajabalian, Nasrin Samadi, Mohammad Ali Faramarzi, Neda Adibpour, Abbas Shafiee, Alireza Foroumadi,

Cancer therapeutics and mechanisms

A number of linezolid analogues containing a nitroaryl-1,3,4-thiadiazole moiety, were prepared and evaluated as antibacterial agents against a panel of Gram-positive and Gram-negative bacteria. Among synthesized compounds, nitrofuran analogue 1b exhibited more potent inhibitory activity, with respect to other synthesized compounds and reference drug linezolid. The target compounds were also assessed for their cytotoxic activity against normal mouse fibroblast (NIH/3T3) cells using MTT assay. The results indicated that compound 1c exhibit potent antibacterial activity against Gram-positive bacteria at non-cytotoxic concentrations.