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Cu-free click cycloaddition reactions in chemical biology

2010; Royal Society of Chemistry; Volume: 39; Issue: 4 Linguagem: Inglês

10.1039/b901970g

1460-4744

John C. Jewett, Carolyn R. Bertozzi,

Monoclonal and Polyclonal Antibodies Research

Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems—in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.