Inhibition of adrenergic neurotransmission by prostaglandin E1 (PGE1) in the rabbit ear artery
1976; Elsevier BV; Volume: 15; Issue: 4 Linguagem: Inglês
10.1016/0028-3908(76)90071-x
ISSN1873-7064
AutoresP. Hadházy, E. Sylvester Vizi, K. Magyar, J. Knoll,
Tópico(s)Receptor Mechanisms and Signaling
ResumoAbstract Isolated central ear arteries of rabbits were perfused with Krebs solution at a constant flow rate of 2–7 ml/min. Pressure changes to periarterial nerve stimulation (1, 3, 10 and 30 Hz; 5–32 pulses) and to noradrenaline were measured in the presence and absence of prostaglandin E 1 (PGE 1 ). This substance in concentrations of 7 × 10 −9 – 4.5 × 10 −7 produced a dose-dependent inhibition of constrictor responses to nerve stimulation. The degree of inhibitory action of PGE 1 became progressively less as the frequency or length of stimulation was increased. Prostaglandin E 1 (1.1 × 10 −7 M) failed to affect the constrictor responses to noradrenaline and it markedly reduced the stimulation-evoked release of radioactivity from arteries incubated with [ 3 ]noradrenaline. The results indicate that PGE 1 inhibits the vasoconstrictor responses of rabbit ear artery to nerve stimulation by reducing the release of the adrenergic transmitter.
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