Delayed development of amnestic behavior after hypoxia
1974; Elsevier BV; Volume: 13; Issue: 5 Linguagem: Inglês
10.1016/0031-9384(74)90242-x
ISSN1873-507X
Autores Tópico(s)Neuroscience of respiration and sleep
ResumoWistar rats were trained in one trial to avoid a small dark compartment after which they were submitted to a 10 min hypoxia or sham hypoxia. Different groups were tested at 1, 3, 6 or 24 hr after treatment. All sham hypoxia groups avoided at all testing times. Hypoxia groups avoided at 1 and 3 hr but not at 6 or 24 hr. The results are interpreted as evidence that hypoxia interferes with memory retrieval and not with memory storage. It is suggested that hypoxia produces a behavioral deficit by triggering an abnormal metabolic sequence of the biochemical substrates which are necessary for the retrieval function.
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