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Dose-Dependent Effect of Atrial Natriuretic Peptide on Blood Pressure, Heart Rate, and Skin Blood Flow of Normal Volunteers

1986; Lippincott Williams & Wilkins; Volume: 8; Issue: 1 Linguagem: Inglês

10.1097/00005344-198601000-00031

1533-4023

J. P. Bussien, Jérôme Biollaz, Bernard Waeber, J. Nussberger, G. A. Turini, Hans R. Brunner, Françoise Brunner‐Ferber, Héctor W. Gómez, E S Otterbein,

Cardiovascular and exercise physiology

Synthetic atrial natriuretic peptide, containing 26 amino acids in the rat sequence, L-364, 343 (Ileu-ANP), was infused intravenously at increasing rates (1-40 micrograms/min) into four normal volunteers. Mean intraarterial blood pressure decreased and heart rate increased in cumulative-dose-dependent fashion. Skin blood flow as measured with a laser Doppler device rose already with a cumulative dose of 55 micrograms Ileu-ANP and further rises were directly related to dose. The only side effects observed were those accompanying symptomatic hypotension at higher doses. These findings provide strong evidence that Ileu-ANP acts as a vasodilator in normal volunteers.