First total synthesis of (+)-hyacinthacine A2
2001; Elsevier BV; Volume: 12; Issue: 13 Linguagem: Inglês
10.1016/s0957-4166(01)00324-x
ISSN1362-511X
AutoresLauriane Rambaud, Philippe Compain, Olivier R. Martin,
Tópico(s)Biochemical and Molecular Research
ResumoThe first synthesis of (+)-hyacinthacine A2 has been achieved in six steps from 2,3,5-tri-O-benzyl-d-arabinofuranose in an overall yield of 11%. The structure of this natural product was thus unambiguously established as (1R,2R,3R,7aR)-1,2-dihydroxy-3-hydroxymethylpyrrolizidine.
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