Portal de Periódicos da CAPES

A comparison of baclofen and diazepam in the treatment of spasticity

1974; Elsevier BV; Volume: 23; Issue: 1 Linguagem: Inglês

10.1016/0022-510x(74)90137-3

1878-5883

N.E.F. Cartlidge, P. Hudgson, Andrew Weightman,

Cerebral Palsy and Movement Disorders

Abstract Baclofen (Lioresal, Ciba) has recently been shown to be significantly more effective than placebo in the treatment of spasticity due to lesions in the spinal cord. A double-blind controlled trial of baclofen against diazepam was carried out at two dose levels and this showed no significant difference between the two drugs. There was, however, a tendency in favour of baclofen, particularly in higher doses. In addition a significant difference in response to baclofen was associated with the weight of patients; this association was not found when they were taking diazepam.