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DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes

1996; Cell Press; Volume: 4; Issue: 6 Linguagem: Inglês

10.1016/s1074-7613(00)70060-4

1097-4180

Akira Shibuya, David G. Campbell, Charles Hannum, Hans Yssel, Karin Franz-Bacon, Terrill K. McClanahan, Toshio Kitamura, Jillian Nicholl, Grant R. Sutherland, Lewis L. Lanier, Joseph H. Phillips,

T-cell and B-cell Immunology

Intercellular adhesion molecules play an important role in the generation of T lymphocyte–mediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa includ- ing two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cell–mediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloanti- gen-specific T cells. In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)–mediated cytotoxicity.