Portal de Periódicos da CAPES

Anti‐CD4 Monoclonal Antibodies in Therapy: Creation of Nonclassical Tolerance in the Adult

1992; Wiley; Volume: 129; Issue: 1 Linguagem: Inglês

10.1111/j.1600-065x.1992.tb01421.x

1600-065X

Judith A. Shiztru, Susan E. Alters, C. Garrison Fathman,

Diabetes and associated disorders

Immunological ReviewsVolume 129, Issue 1 p. 105-130 Anti-CD4 Monoclonal Antibodies in Therapy: Creation of Nonclassical Tolerance in the Adult Judith A. Shiztru, Judith A. Shiztru Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, California, USA.Search for more papers by this authorSusan E. Alters, Susan E. Alters Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, California, USA.Search for more papers by this authorC. Garrison Fathman, Corresponding Author C. Garrison Fathman Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, California, USA.Address correspondence to: C. Garrison Fathman, M.D., Stanford University School of Medicine, Division of Rheumatology and Immunology, Room S021, Stanford, CA, USA 94305.Search for more papers by this author Judith A. Shiztru, Judith A. Shiztru Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, California, USA.Search for more papers by this authorSusan E. Alters, Susan E. Alters Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, California, USA.Search for more papers by this authorC. Garrison Fathman, Corresponding Author C. Garrison Fathman Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, California, USA.Address correspondence to: C. Garrison Fathman, M.D., Stanford University School of Medicine, Division of Rheumatology and Immunology, Room S021, Stanford, CA, USA 94305.Search for more papers by this author First published: October 1992 https://doi.org/10.1111/j.1600-065X.1992.tb01421.xCitations: 42AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Acha-Orbea, H., Steinman, L. & McDevitt, H. O. (1989) T cell receptors in murine autoimmune diseases. Ann. Rev. Immunol. 7, 371. Alexander, D. R. & Cantrell, D. A. (1989) Kinases and phosphatases in T-cell activation. Immunol. Today. 10, 200. Alters, S. E., Sakai, K., Steinman, L. & Oi, V. (1990) Mechanisms of anti-CD4 mediated depletion and immunotherapy: a study using a set of chimeric anti-CD4 antibodies. J. Immunol. 144, 4587. Alters, S. E., Shizuru, J. A., Ackerman, J., Grossman, D., Seydel, K. B. & Fathman, C. G. (1991) Anti-CD4 mediates clonal anergy during transplantation tolerance induction. J. Exp. Med. 173, 741. Alters, S. E. Steinman, L. & Oi, V. T. (1989) Comparison of rat and rat-mouse chimeric anti-murine CD4 antibodies in vitro: chimeric antibodies lyse low density CD4+ cells. J. Immunol. 142, 2018. Armstrong, H. E., Bolton, E. M., McMillan, I., Spencer, S. C. & Bradley, J. A. (1987) Prolonged survival of actively enhanced rat renal allografts despite accelerated cellular infiltration. J. Exp. Med. 165, 891. Armstrong, H. E., Bolton, E. M., McMillan, I., Spencer, S. C & Bradley, J. A. (1987) Prolonged survival of actively enhanced rat renal allografts despite accelerated cellular infiltration. J. Exp. Med. 165, 891. Auchincloss, H., Ghobrial, R. R. M., Russell, P. S. & Winn, H. J. (1988) Prevention of antibody formation after skin grafting without prolongation of graft survival by anti-L3T4 in vivo. Transplantation 45, 1118. Bank, I. & Chess, L. (1985) Perturbation of the T4 molecule transmits a negative signal to cells. J. Exp. Med. 162, 1294. Benjamin, R. J., Qin, S., Wise, M., Cobbold, S. & Waldmann, H. (1988) Mechanisms of monoclonal antibody facilitated tolerance induction: possible role for the CD4 (L3T4) and CD11a (LFA-2) molecules in self-non-self discrimination. Eur. J. Immunol. 17, 1079. Benjamin, R. J. & Waldmann, H. (1986) Induction of tolerance by monoclonal antibody therapy. Nature 320, 449. Bill, J. Apple, V. & Palmer, E. (1988) An analysis of T-cell receptor V-gene expression in MHC-disparate mice. Proc. Natl. Acad. Sci. USA 85, 1198. Bill, J., Kanagawa, C. Woodland, D. & Palmer, E. (1989) The MHC molecule I-E is necessary but not sufficient for clonal deletion of Vb11 bearing T cells. J. Exp. Med. 169, 1405. Billingham, E. R., Brent, L. & Medawar, P. B. (1953) Actively acquired tolerance to foreign cells. Nature 172, 603. Birkland, M. L., Johnson, P., Trowbridge, I. S. & Pure, E. (1989) Changes in CD45 isoform expression accompanying antigen-induced murine T-cell activation. Proc. Natl. Acad. Sci. USA 86, 6734. Brostoff, S. W. & Mason, D. W. (1984) Experimental allergic encephalomyelitis: a successful treatment in vivo with a monoclonal antibody that recognizes T helper cells. J. Immunol. 133, 1938. Budd, R. C. Cerrotini, J. C. Horvath, C. Bron, C. Pediazzini, T. Howe, R. C. & MacDonald, H. R. (1987) Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigen stimulation. J. Immunol. 138, 3120. Burkhardt, K., Charlton, B. & Mandel, T. E. (1989) An increase in the survival of murine H-2 mismatched cultured fetal pancreas allografts using depleting or non-depleting anti-CD4 monoclonal antibodies, and a further increase with the addition of cyciosporine. Transplantation 47, 771. Butterfield, K., Fathman, C. G. & Budd, R. C. (1989) A subset of memory CD4* helper T lymphocytes identified by expression of Pgp-1. J. Exp. Med. 169, 1461. Cantor, H. & Boyse, E. A. (1975) Functional subclasses of T lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T cell subclasses in a differentiative process independent of antigen. J. Exp. Med. 141, 1376. Carteron, N. L., Schmenti, C. L. & Wofsy, D. (1989) Treatment of murine lupus with F(ab′)2 fragments of monoclonal antibody to L3T4: suppression of autoimmunity does not depend on T helper cell depletion. J. Immunol. 142, 1470. Carteron, N. L., Wofsy, D. & Seaman, W. E. (1988) Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells. J. Immunol. 140, 713. Charleton, B. & Mandel, T. E. (1988) Progression from insulitis to b cell destruction in the NOD mouse required L3T4+ T cells. Diabetes 37, 1108. Charlton, B. & Mandel, T. E. (1989) Tolerance to aggregated human IgG but not ovalbumin can be induced by concurrent administration of depleting or non-depleting anti-L3T4 monoclonal antibodies. Immunol. Cell Biol. 67, 1. Christadoss, P. & Dauphinee, M. J. (1986) Immunotherapy for myasthenia gravis: a murine model. J. Immunol. 135, 1001. Cobbold, S. P., Jayasuriya, A., Nash, A., Prospero, T. D. & Waldmann, H. (1984) Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312, 548. Dallman, M., Wood, K. J. & Moris, P. J. (1987) Specific cytotoxic T cells are found in the nonrejected kidneys of blood transfused rats. J. Exp. Med. 165, 566. Dialynas, P. R. Wilde, D. B., Marrack, P., Pierres, A., Wall, K. A., Harran, W. Otten, G., Loken, M. R., Pierres, M., Kappler, J. & Fitch, F. W. (1983) Characterization of the murine antigenic determinant designated L3T4a, recognized by monoclonal antibody GKl.5: expression of L3T4a by functional T cell clones appears to correlate primarily with Class II MHC reactivity. Immunol. Rev. 74, 29. Eichmann, K., Boyce, N. W. Schmidt-Ullrich, R. & Jonsson, J. I. (1989) Distinct functions of CD8 (CIM) are utilized at different sttes of T lymphocyte-differentiation. Immunol. Rev. 109, 39. Eisenbarth, G. S. (1986) Type I diabetes mellitus: a chronic autoimmune disease. N. Engl. J. Med. 314, 1360. Engleman, E. G., Benike, C. J., Glickman, E. & Evans, R. L. (1981) Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man. J. Exp. Med. 153, 193. Flavin, T. Shizuru, J. A., Seydel, K., Wu, A. R. Fujimoto, N., Hoyt, E. G., Ivens, K., Billingham, M. E., Fathman, C. G. & Stames, V. A. (1990) Selective T cell depletion with OX-38 anti-CD4 monoclonal antibody prevents cardiac allograft rejection in rats. J. Heart Transplant 5, 483. Goronzy, J., Weyand, C. M. & Fathman, C. G. (1986) Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4. J. Exp. Med. 164, 911. Greenstein, J. L. & Burakoff, S. J. (1987) The role of L3T4 (CD4) in T cell activation. Ann. Inst. Pasteur Immunol. 138, 134. Hao, L., Wang, Y. Gill, R. G. & Lafferty, K. J. (1987) Role of the L3T4+ T cell in allograft rejection. J. Immunol. 139, 4022. Herbert, J. & Roser, B. (1988) Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants. Transplantation 46, 128. Herzog, C. H., Walker, C. H. & Muller, W. (1989) Anti-CD4 antibody treatment of patients with rheumatoid arthritis. I. Effect on clinical course and circulating T cells. J. Autoimmun. 2, 627. Janeway, C. A., Rojo, J., Saizawa, K., Dianani, U., Portoles, P., Tite, J., Haque, S. & Jones, B. (1989) The co-receptor function of murine CD4. Immunol. Rev. 109, 77. Jenkins, M., Pardoll, D. Mizuguchi, J., Chused, T & Schwartz, R. (1987) Molecular events in the induction of a nonresponsive state in interieukin-2-producing helper T lymphocyte clones. Proc. Natl. Acad. Sci. USA 84, 5409. Jenkins, M. K. & Schwartz, R. H. (1987) Antigen presentation by chemically modified splenocytes induces antigen specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med 165, 302. Kappler, J. W. Roehm, N. & Marrack, P. (1987) T cell tolerance by clonal elimination in the thymus. Cell 49, 273. Kappler, J. W., Staerz, U., White, J. & Marrack, P. (1988) Self tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332, 35. Kappler, J. W., Wade, T. White, J. Kushnir, E., Blackman, M., Bill, J., Roehm, N. & Marrack, P. (1987) A T cell receptor Vb segment that imparts reactivity to a Class II major histocompatibility complex product. Cell 49, 263. Kaufman, D. S., Kong, C. D., Shizuru, J. A., Gregory, A. K. & Fathman, C. G. (1988) Use of anti-L3T4 and anti-la treatments for prolongation of xenogeneic islet transplants. Transplantation 46, 210. Koike, T. Itoh, Y., Ishii, T. Ito, I., Takabayashi, K. Maruyama, N., Tomioka, H. & Yoshida, S. (1987) Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice. Diabetes 36, 539. Lacy, P. E., Ricordi, C. & Finke, E. H. (1989) Effect of transplantation site and anti-L3T4 treatment on survival of rat, hamster, and rabbit islet xenografts in mice. Transplantation 47, 761. Lafferty, K., Prowse, S. J., Simeonovic, C. J. & Warren, H. S. (1983) Immunology of tissue transplantation: a return to the passenger leukocyte concept. Ann. Rev. Immunol. 1, 143. Lindstrom, J., Shelton, D. & Fuji, Y. (1988) Myasthenia gravis. Adv. Immunol. 42, 233. Madsen, J. D., Pugh, W. M., Wood, K. J. & Morris, P. J. (1987) The effect of anti-L3T4 monoclonal antibody treatment on first-set rejection of murine cardiac allografts. Transplantation 44, 849. Makino, S., Kunimoto, K., Muraoka, Y. Mizushima, Y. Katagiri, K. & Tochino, Y. (1980) Breeding of a non-obese non-diabetic strain of mice. Exp. Anim. 29, I. Marrack, P. & Kappler, J. (1988) T cells can distinguish between allogeneic major histocompatibility complex products on different cells types. Nature 332, 840. Matzinger, P. & Bevan, M. J. (1977) Hypothesis: Why do so many lymphocytes respond to major histocompatibility antigens. Celt. Immunol. 29, 1. McFarlin, D. E., Blank, S. E., Kibler, R. F., McKneally, S. & Shapira, R. (1973) Experimental allergic encephalomyelitis in the rat: Response to encephalitogenic proteins and peptides. Science 179, 478. Mohler, K. M. & Streilein, J. M. (1987) Tolerance to Class II major histocompatibility molecules is maintained in the presence of endogenous interleukin-2 producing tolerogen specific T lymphocytes. J. Immunol. 139, 2211. Morel, R. Vincent, C. Cordier, G., Panaye, G., Corsella, E. & Revillar, J. R. (1990) Anti-CD4 monoclonal antibody administration in renal transplanted patients, din. Immunol. Immunopathol. 56, 311. Mottram, P. L., Wheelahan, J., Mirisklavos, A., Clunie, G. J. A. & McKenzie, I. F. C. (1987) Prolongation of murine cardiac allografts following treatment of graft recipients with monoclonal anti-L3T4 and Ly-2 antibodies. Transplant. Proc. 19, 582. Nepom, G. T. (1988) Immunogenetics of the HLA-associated diseases. Concepts Immunopath. 5, 80. Paterson, P. Y. (1976) Experimental autoimmune (allergic) encephalomyelitis: Induction, pathogenesis, and suppression, in: Textbook of Immunopathology, P. A. Miescher & H. J. Muller-Eberhard, eds. pp. 179–213. New York , Grune & Stratton. Qin, S., Cobbold, S., Tighe, H., Benjamin, R. & Waldmann, H. (1987) CD4 monoclonal antibody pairs for immunosuppression and tolerance induction. Eur. J. Immunol. 17, 1159. Rammensee, H. G., Roschewski, R. & Frangoulis, B. (1989) Clonal anergy induced in mature VjS6+T lymphocytes on immunizing Mls-l*mice with Mls-1*ast; expressing cells. Nature 339, 541. Ramsdell, F., Lantz, T. & Fowlkes, B. (1989) A nondeletional mechanism of thymic self tolerance. Science 246, 1038. Ranges, G. E., Sriram, S. & Cooper, S. M. (1985) Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J. Exp. Med. 162, 1105. Reinherz, E. L. & Schlossmann, S. F. (1980) The differentiation and function of human T lymphocytes. Cell 19, 821. Rosenberg, A. A., Mizuichi, T. & Singer, A. (1986) Analysis of T cell subsets in rejection of Kb mutant skin allografts differing at Class I MHC. Nature 322, 829. Roser, B. (1989) Cellular mechanisms in neonatal and adult tolerance. Immunol. Rev. 107, 179. Sablinski, T. Hancock, W. W. Tilney, N. L. & Kupiec-Weglinski, J. W. (1991) CD4 monoclonal antibodies in organ transplantation - a review of progress. Transplantation 52, 579. Samuelson, L. E., Patel, M. D. Weissman, A. M., Harford, J. B. & Klausner, R. D. (1986) Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 46, 1083. Schwartz, R. H. (1990) A cell culture model for T lymphocyte clonal anergy. Science 248, 1349. Seydel, K. B., Shizuru, J. A., Wu, A. P., Grossman, D. & Fathman, C. G. (1991) Anti-CD8 abrogates the effect of anti-CD4 mediated islet allograft survival in a rat model. Diabetes 40, 1430. Shimonkevitz, R., Kappler, J., Marrack, P. & Grey, H. (1983) Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J. Exp. Med. 158, 303. Shizuru, J. A., Gregory, A. K., Chao, C. T. & Fathman, C. G. (1987) Islet allograft survival after a single course of treatment with antibody to L3T4. Science 37, 278. Shizuru, J. A., Seydel, K. B., Flavin, T F., Wu, A. P. Kong, C. C. Hoyt, E. G., Fujimoto, N., Billingham, M. E., Stames, V. A. & Fathman, C. G. (1990) Pre-transplant anti-CD4 monoclonal antibody therapy induces donor unresponsiveness to cardiac allografts in rat. Transplantation 50, 366. Shizuru, J. A., Taylor-Edwards, C. Banks, B. A., Gregory, A. K. & Fathman, C. G. (1988) Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 240, 659. Song, H. K., Alters, S. E. & Fathman, C. G. (1992) Anti-CD8 abrogates anti-CD4 mediated clonal anergy but allows allograft survival in mice. Transplantation (in press). Sprent, J. & Schaefer, M. (1986) Capacity of purified Lyt-2* T cells to mount primary proliferative and cytotoxic responses to la-tumour cells. Nature 322, 541. Stuart, J. M., Townes, A. S. & Karg, A. H. (1984) Collagen autoimmune arthritis. Ann. Rev. Immunol. 2, 199. Tonks, N. K., Charbonneau, H., Diltz, C. D., Fischer, E. H. & Walsh, K. A. (1988) Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase. Biochemistry 27, 8695. Trager, D. K., Banks, B. A., Holm, B. I., Shizuru, J. A., Strober, S. & Fathman, C. G. (1989) Cardiac allograft prolongation in mice treated with combined post-transplant total lymphoid irradiation and anti-L3T4 antibody therapy. Transplantation 47, 587. Trowbridge, I. S., Lesley, J. Schulte, R., Hyman, R. & Trotter, J. (1982) Biochemical characterization and cellular distribution of a polymorphic murine cell surface glycoprotein expressed on lymphoid cells. Immunogenetics 15, 299. Veillette, A., Bookman, M. A., Horak, E. M. & Bolen, J. B. (1988) The CD4 and CD8 T cell surface antigens are associated with internal membrane tyrosine-protein kinase p56kk. Cell 55, 301. Waldor, M. K., Sriram, S., Hardy, R., Herzenberg, L. A., Lanier, L., Lim, M. & Steinman, L. A. (1985) Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T cells subset marker. Science 227, 415. Waldor, M. K., Mitchell, D., Kipps, T. J., Herzenberg, L. A. & Steinman, L. (1987) Importance of immunoglobulin isotype in therapy of experimental allergic encephalomyelitis with monoclonal antibody-CD4 antibody. J. Immunol. 139, 3660. Weiss, A., Desai, D. Graber, M., Picus, J. & Koretzsky, G. (1991) The regulation of T-cell antigen receptor signal transduction function. Transplant. Proc. 23, 32. Weyand, C. M., Goronzy, J., Swarztrauber, K. & Fathman, C. G. (1989a) Immunosuppression by anti-CD4 treatment in vivo: cellular and humoral responses to alloantigens. Transplantation 47, 1039. Weyand, C. M., Goronzy, J., Swarztrauber, K. & Fathman, C. G. (1989b) Immunosuppression by anti-CD4 treatment in vivo: persistence of secondary antiviral immune responses. Transplantation 47, 1034. Wilde, D. B., Marrack, J., Kappler, Dialynas, D. & Fitch, F. W. (1983) Evidence implicating L3T4 in class II MHC antigen reactivity: monoclonal antibody GKl.5 (anti-L3T4a) block class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J Immunol. 131, 2178. Wofsy, D., Mayes, D. C. Woodcock, J. & Seaman, W. E. (1985a) Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: Studies with soluble antigens in intact mice. J. Immunol. 135, 1698. Wofsy, D. & Seaman, W. E. (1985) Successful treatment of autoimmunity in NZB/NZW Fl mice with monoclonal antibody to L3T4. J. Exp. Med. 161, 378. Citing Literature Volume129, Issue1October 1992Pages 105-130 ReferencesRelatedInformation