First Total Synthesis of Cytotoxic Diarylheptanoids, Galeon, and Pterocarine
2007; Taylor & Francis; Volume: 37; Issue: 5 Linguagem: Inglês
10.1080/00397910601131015
ISSN1532-2432
AutoresQian Wang, Jong‐Keun Son, Yurngdong Jahng,
Tópico(s)Curcumin's Biomedical Applications
ResumoAbstract The first total synthesis of cytotoxic diphenyl ether‐type diarylheptanoids, galeon and pterocarine, was described in which the Ullmann reaction was employed at the final step for the diaryl ether formation of key intermediate, 1‐(3‐bromo‐4‐benzyloxyphenyl)‐7‐(4‐hydroxy‐3‐methoxyphenyl)heptan‐3‐one, assembled by a series of cross‐aldol condensation from 3‐methoxy‐4‐benzyloxybenzaldehyde.
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