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Combined treatment with cholestyramine and nicotinic acid in heterozygous familial hypercholesterolaemia: effects on biliary lipid composition

1986; Wiley; Volume: 16; Issue: 5 Linguagem: Inglês

10.1111/j.1365-2362.1986.tb01014.x

1365-2362

Bo Angelin, Mats Eriksson, Kurt Einarsson,

Cholesterol and Lipid Metabolism

Abstract In ten patients with heterozygous familial hypercholesterolaemia, combination therapy with cholestyramine and nicotinic acid was instituted for a minimum of 2 months. During therapy, plasma low‐density lipoprotein levels were reduced by 32%, and low‐density lipoprotein to high‐density lipoprotein ratios by 40%. The cholesterol saturation of fasting gall‐bladder bile was reduced by 33% during treatment. We conclude that long‐term combination therapy with cholestyramine and nicotinic acid is practically feasible in heterozygous familial hypercholesterolaemia, normalizes plasma cholesterol and low‐density lipoprotein levels in many patients, and does not result in unwanted side‐effects on biliary lipids. It should therefore be considered as the therapy of choice in this condition.