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Garlic (Allium sativum L.) as a Potential Antidote for Cadmium and Lead Intoxication: Cadmium and Lead Distribution and Analysis in Different Mice Organs

2007; Springer Science+Business Media; Volume: 120; Issue: 1-3 Linguagem: Inglês

10.1007/s12011-007-8017-3

1559-0720

Adnan M. Massadeh, Saafan A. Al-Safi, Idrees F. Momani, Ahmed A. Alomary, Qasem M. Jaradat, A. Alkofahi,

Nephrotoxicity and Medicinal Plants

Analysis and distribution of Pb and Cd in different mice organs including liver, kidney, spleen, heart and blood were evaluated after treatment with different aqueous concentrations of garlic (12.5–100 mg/l). Atomic absorption spectrometry (AAS) was used for analysis of Pb and Cd in these organs. Treatment of Cd–Pb exposed mice with garlic (12.5–100 mg/l) reduced Pb concentrations by 44.65, 42.61, 38.4, 47.56, and 66.62% in liver, kidney, heart, spleen and blood respectively. Moreover, garlic reduced Cd levels by 72.5, 87.7, 92.6, 95.6, and 71.7% in liver, kidney, heart, spleen and blood respectively. The suppressed immune responses in mice pretreated with Cd–Pb mixture were reversed by 48.85, 55.82, 81.4 and 90.7 in the presence of 100, 50, 25, and 12.5 mg/ml of garlic extract.