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Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells

2013; Elsevier BV; Volume: 95; Issue: 2 Linguagem: Inglês

10.1016/j.yexmp.2013.06.003

1096-0945

Shaukat Khan, Johannes Nowatzky, Sonia Jiménez-Branda, Jeffrey David Greenberg, Robert M. Clancy, Jill P. Buyon, Nina Bhardwaj,

T-cell and B-cell Immunology

The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus.Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI ≥ 4) or "inactive" (SLEDAI < 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation.The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality.cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.