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Propofol administration is safe in adult eosinophilic esophagitis patients sensitized to egg, soy, or peanut

2014; Wiley; Volume: 69; Issue: 3 Linguagem: Inglês

10.1111/all.12360

1398-9995

Javier Molina‐Infante, Ángel Arias, Daniel Vara-Brenes, Raúl Prados-Manzano, Jesús González‐Cervera, Manuela Alvarado-Arenas, Alfredo J. Lucendo,

Eosinophilic Esophagitis

AllergyVolume 69, Issue 3 p. 388-394 Original Article Propofol administration is safe in adult eosinophilic esophagitis patients sensitized to egg, soy, or peanut J. Molina-Infante, Corresponding Author J. Molina-Infante Department of Gastroenterology, Hospital San Pedro de Alcantara, Caceres, Spain Correspondence Javier Molina-Infante, Department of Gastroenterology, Hospital San Pedro de Alcantara, C/ Pablo Naranjo s/n 10003, Caceres, Spain. Tel.: +0034-627430248 Fax: +0034-927621545 E-mail: xavi_molina@hotmail.comSearch for more papers by this authorA. Arias, A. Arias Research Unit, Hospital Alcazar de San Juan, Ciudad Real, SpainSearch for more papers by this authorD. Vara-Brenes, D. Vara-Brenes Department of Gastroenterology, Hospital San Pedro de Alcantara, Caceres, SpainSearch for more papers by this authorR. Prados-Manzano, R. Prados-Manzano Department of Gastroenterology, Hospital San Pedro de Alcantara, Caceres, SpainSearch for more papers by this authorJ. Gonzalez-Cervera, J. Gonzalez-Cervera Department of Allergy, Hospital General de Tomelloso, Ciudad Real, SpainSearch for more papers by this authorM. Alvarado-Arenas, M. Alvarado-Arenas Department of Allergy, Hospital San Pedro de Alcantara, Caceres, SpainSearch for more papers by this authorA. J. Lucendo, A. J. Lucendo Department of Gastroenterology, Hospital General de Tomelloso, Ciudad Real, SpainSearch for more papers by this author J. Molina-Infante, Corresponding Author J. Molina-Infante Department of Gastroenterology, Hospital San Pedro de Alcantara, Caceres, Spain Correspondence Javier Molina-Infante, Department of Gastroenterology, Hospital San Pedro de Alcantara, C/ Pablo Naranjo s/n 10003, Caceres, Spain. Tel.: +0034-627430248 Fax: +0034-927621545 E-mail: xavi_molina@hotmail.comSearch for more papers by this authorA. Arias, A. Arias Research Unit, Hospital Alcazar de San Juan, Ciudad Real, SpainSearch for more papers by this authorD. Vara-Brenes, D. Vara-Brenes Department of Gastroenterology, Hospital San Pedro de Alcantara, Caceres, SpainSearch for more papers by this authorR. Prados-Manzano, R. Prados-Manzano Department of Gastroenterology, Hospital San Pedro de Alcantara, Caceres, SpainSearch for more papers by this authorJ. Gonzalez-Cervera, J. Gonzalez-Cervera Department of Allergy, Hospital General de Tomelloso, Ciudad Real, SpainSearch for more papers by this authorM. Alvarado-Arenas, M. Alvarado-Arenas Department of Allergy, Hospital San Pedro de Alcantara, Caceres, SpainSearch for more papers by this authorA. J. Lucendo, A. J. Lucendo Department of Gastroenterology, Hospital General de Tomelloso, Ciudad Real, SpainSearch for more papers by this author First published: 21 January 2014 https://doi.org/10.1111/all.12360Citations: 32 Edited by: Hans-Uwe Simon Guarantor of the article: Alfredo J. Lucendo Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background Sedation might improve tolerability and adherence to endoscopic procedures in patients with eosinophilic esophagitis (EoE). Propofol administration is often contraindicated in patients with hypersensitivity to egg, soy, or peanut. Objective To investigate the safety of propofol administration for procedural sedation in EoE patients sensitized/allergic to egg, soy, peanut. Methods A retrospective observational study in adult EoE patients undergoing esophagogastroduodenoscopy with propofol sedation was conducted between January 2009 and March 2013. Food-specific serum IgE and skin prick tests for egg, soy, peanut, and cross-reactant foods were performed in all patients. Results Sixty EoE adult patients, mostly on food elimination diets (91%), were evaluated (age: 28 years (14–56), male gender (90%)). Atopy was present in 88% of patients, being the most prevalent comorbidities rhinoconjunctivitis (78%) and asthma (67%). Fifty-two patients (86%) were sensitized to either egg, soy, or peanut. Eighteen patients (28%) had a history of allergic reactions to egg, legumes, and nuts and strictly avoided these foods. A total of 404 upper endoscopies were performed under propofol sedation. No allergic adverse events were reported, except a transient bronchospasm after orotracheal intubation in an asthmatic adolescent receiving multiple drugs for anesthesia, in whom no sensitization to either propofol or its lipid vehicle was confirmed. Conclusions Propofol was safely administered for procedural sedation in a large series of adult EoE patients multisensitized to egg, soy, peanut, showing one-third clinical allergy to these foods. Citing Literature Volume69, Issue3March 2014Pages 388-394 RelatedInformation