Acetogenins from seeds of Annona reticulata
1998; Elsevier BV; Volume: 47; Issue: 6 Linguagem: Inglês
10.1016/s0031-9422(98)80072-1
ISSN1873-3700
AutoresFang‐Rong Chang, Jien-Lin Chen, Hui‐Fen Chiu, Ming-Jung Wu, Wu Yang-Chang,
Tópico(s)Phytochemical compounds biological activities
ResumoChromatography of an ethyl acetate extract of seeds of Annona reticulata led to the isolation of a new cytotoxic γ-lactone acetogenin, cis-/trans-isomurisolenin, along with six known cytotoxic acetogenins, annoreticuin, annoreticuin-9-one, bullatacin, squamocin, cis-/trans-bullatacinone and cis-/trans-murisolinone. Structures of these compounds were established by means of mass and related spectral experiments. Some of the compounds isolated, showed potent cytotoxicities against Hep. 2,2,15, Hep. G2, KB and CCM2, four cancer cell-lines.
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