Synthesis of Highly Substituted Pyridazines through Alkynyl Boronic Ester Cycloaddition Reactions
2005; Wiley; Volume: 44; Issue: 25 Linguagem: Inglês
10.1002/anie.200500288
ISSN1521-3773
AutoresMatthew Helm, Jane E. Moore, Andrew Plant, Joseph P. A. Harrity,
Tópico(s)Chemical Synthesis and Analysis
ResumoA highly regioselective transformation of tetrazines through a cycloaddition reaction with alkynyl boronic esters provides highly substituted pyridazine boronic esters as intermediates for CO and CC bond-forming reactions (see scheme). Functionalization reactions of the CB bond, such as oxidation and the Suzuki cross-coupling, show the versatility of these species.
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